diff --git a/src/device/isamem.c b/src/device/isamem.c
index a53f5e66c..fcbbbfb15 100644
--- a/src/device/isamem.c
+++ b/src/device/isamem.c
@@ -2145,3 +2145,12 @@ isamem_get_device(int board)
     /* Add the instance to the system. */
     return boards[board].dev;
 }
+
+int
+isamem_has_config(int board)
+{
+    if (boards[board].dev == NULL)
+        return 0;
+
+    return (boards[board].dev->config ? 1 : 0);
+}
diff --git a/src/device/isartc.c b/src/device/isartc.c
index 46f31c137..fea108426 100644
--- a/src/device/isartc.c
+++ b/src/device/isartc.c
@@ -815,3 +815,12 @@ isartc_get_device(int board)
 {
     return (boards[board].dev);
 }
+
+int
+isartc_has_config(int board)
+{
+    if (boards[board].dev == NULL)
+        return 0;
+
+    return (boards[board].dev->config ? 1 : 0);
+}
diff --git a/src/include/86box/isamem.h b/src/include/86box/isamem.h
index 9a1841c53..51fe50e33 100644
--- a/src/include/86box/isamem.h
+++ b/src/include/86box/isamem.h
@@ -64,6 +64,7 @@ extern const char     *isamem_get_name(int t);
 extern const char     *isamem_get_internal_name(int t);
 extern int             isamem_get_from_internal_name(const char *s);
 extern const device_t *isamem_get_device(int t);
+extern int             isamem_has_config(int board);
 
 #ifdef __cplusplus
 }
diff --git a/src/include/86box/isartc.h b/src/include/86box/isartc.h
index 92c58e350..0224180b3 100644
--- a/src/include/86box/isartc.h
+++ b/src/include/86box/isartc.h
@@ -58,6 +58,7 @@ extern void isartc_reset(void);
 extern const char     *isartc_get_internal_name(int t);
 extern int             isartc_get_from_internal_name(char *s);
 extern const device_t *isartc_get_device(int t);
+extern int             isartc_has_config(int board);
 
 #ifdef __cplusplus
 }
diff --git a/src/qt/qt_settingsotherperipherals.cpp b/src/qt/qt_settingsotherperipherals.cpp
index 3904b653a..a7db551ad 100644
--- a/src/qt/qt_settingsotherperipherals.cpp
+++ b/src/qt/qt_settingsotherperipherals.cpp
@@ -81,6 +81,7 @@ SettingsOtherPeripherals::onCurrentMachineChanged(int machineId)
         ++d;
     }
     ui->comboBoxRTC->setCurrentIndex(selectedRow);
+    ui->pushButtonConfigureRTC->setEnabled((isartc_type != 0) && isartc_has_config(isartc_type) && machineHasIsa);
 
     for (int c = 0; c < ISAMEM_MAX; c++) {
         auto *cbox  = findChild<QComboBox *>(QString("comboBoxCard%1").arg(c + 1));
@@ -106,7 +107,7 @@ SettingsOtherPeripherals::onCurrentMachineChanged(int machineId)
         cbox->setCurrentIndex(-1);
         cbox->setCurrentIndex(selectedRow);
         cbox->setEnabled(machineHasIsa);
-        findChild<QPushButton *>(QString("pushButtonConfigureCard%1").arg(c + 1))->setEnabled(isamem_type[c] != 0 && machineHasIsa);
+        findChild<QPushButton *>(QString("pushButtonConfigureCard%1").arg(c + 1))->setEnabled((isamem_type[c] != 0) && isamem_has_config(isamem_type[c]) && machineHasIsa);
     }
 }
 
@@ -138,7 +139,7 @@ SettingsOtherPeripherals::on_comboBoxRTC_currentIndexChanged(int index)
     if (index < 0) {
         return;
     }
-    ui->pushButtonConfigureRTC->setEnabled(index != 0 && machine_has_bus(machineId, MACHINE_BUS_ISA));
+    ui->pushButtonConfigureRTC->setEnabled((index != 0) && isartc_has_config(index) && machine_has_bus(machineId, MACHINE_BUS_ISA));
 }
 
 void
@@ -153,7 +154,7 @@ SettingsOtherPeripherals::on_comboBoxCard1_currentIndexChanged(int index)
     if (index < 0) {
         return;
     }
-    ui->pushButtonConfigureCard1->setEnabled(index != 0 && machine_has_bus(machineId, MACHINE_BUS_ISA));
+    ui->pushButtonConfigureCard1->setEnabled((index != 0) && isamem_has_config(index) && machine_has_bus(machineId, MACHINE_BUS_ISA));
 }
 
 void
@@ -168,7 +169,7 @@ SettingsOtherPeripherals::on_comboBoxCard2_currentIndexChanged(int index)
     if (index < 0) {
         return;
     }
-    ui->pushButtonConfigureCard2->setEnabled(index != 0 && machine_has_bus(machineId, MACHINE_BUS_ISA));
+    ui->pushButtonConfigureCard2->setEnabled((index != 0) && isamem_has_config(index) && machine_has_bus(machineId, MACHINE_BUS_ISA));
 }
 
 void
@@ -183,7 +184,7 @@ SettingsOtherPeripherals::on_comboBoxCard3_currentIndexChanged(int index)
     if (index < 0) {
         return;
     }
-    ui->pushButtonConfigureCard3->setEnabled(index != 0 && machine_has_bus(machineId, MACHINE_BUS_ISA));
+    ui->pushButtonConfigureCard3->setEnabled((index != 0) && isamem_has_config(index) && machine_has_bus(machineId, MACHINE_BUS_ISA));
 }
 
 void
@@ -198,7 +199,7 @@ SettingsOtherPeripherals::on_comboBoxCard4_currentIndexChanged(int index)
     if (index < 0) {
         return;
     }
-    ui->pushButtonConfigureCard4->setEnabled(index != 0 && machine_has_bus(machineId, MACHINE_BUS_ISA));
+    ui->pushButtonConfigureCard4->setEnabled((index != 0) && isamem_has_config(index) && machine_has_bus(machineId, MACHINE_BUS_ISA));
 }
 
 void