diff --git a/src/duckstation-qt/advancedsettingswidget.cpp b/src/duckstation-qt/advancedsettingswidget.cpp
index 23499307b..1b6c178c3 100644
--- a/src/duckstation-qt/advancedsettingswidget.cpp
+++ b/src/duckstation-qt/advancedsettingswidget.cpp
@@ -418,7 +418,8 @@ void AdvancedSettingsWidget::onResetToDefaultClicked()
   sif->DeleteValue("PCDrv", "Enabled");
   sif->DeleteValue("PCDrv", "EnableWrites");
   sif->DeleteValue("PCDrv", "Root");
-  sif->Save();
+  QtHost::SaveGameSettings(sif, true);
+  g_emu_thread->reloadGameSettings();
   while (m_ui.tweakOptionTable->rowCount() > 0)
     m_ui.tweakOptionTable->removeRow(m_ui.tweakOptionTable->rowCount() - 1);
   addTweakOptions();