diff --git a/Radzen.Blazor.Tests/DataGridTests.cs b/Radzen.Blazor.Tests/DataGridTests.cs
index fb0016a45..010784a79 100644
--- a/Radzen.Blazor.Tests/DataGridTests.cs
+++ b/Radzen.Blazor.Tests/DataGridTests.cs
@@ -3447,6 +3447,35 @@ namespace Radzen.Blazor.Tests
             Assert.False(string.IsNullOrEmpty(wrapper.GetAttribute("aria-activedescendant")));
         }
 
+        [Fact]
+        public void DataGrid_ActiveDescendant_IsClearedWhenNoActiveRow()
+        {
+            using var ctx = new TestContext();
+            ctx.JSInterop.Mode = JSRuntimeMode.Loose;
+            ctx.JSInterop.SetupModule("_content/Radzen.Blazor/Radzen.Blazor.js");
+
+            var component = ctx.RenderComponent<RadzenDataGrid<dynamic>>(parameterBuilder =>
+            {
+                parameterBuilder.Add<IEnumerable<dynamic>>(p => p.Data, new[] { new { Id = 1 }, new { Id = 2 } });
+                parameterBuilder.Add<RenderFragment>(p => p.Columns, builder =>
+                {
+                    builder.OpenComponent(0, typeof(RadzenDataGridColumn<dynamic>));
+                    builder.AddAttribute(1, "Property", "Id");
+                    builder.CloseComponent();
+                });
+            });
+
+            var instance = component.Instance;
+
+            Assert.False(string.IsNullOrEmpty(instance.GetActiveDescendantId()));
+
+            instance.HasActiveDescendant = () => false;
+            Assert.Null(instance.GetActiveDescendantId());
+
+            instance.HasActiveDescendant = () => true;
+            Assert.False(string.IsNullOrEmpty(instance.GetActiveDescendantId()));
+        }
+
         [Fact]
         public void DataGrid_AppliesAriaGridRolesToTableDescendants()
         {
diff --git a/Radzen.Blazor/RadzenDataGrid.razor.cs b/Radzen.Blazor/RadzenDataGrid.razor.cs
index 5bea99c6d..0675f3065 100644
--- a/Radzen.Blazor/RadzenDataGrid.razor.cs
+++ b/Radzen.Blazor/RadzenDataGrid.razor.cs
@@ -598,8 +598,15 @@ namespace Radzen.Blazor
         int focusedIndex = -1;
         int focusedCellIndex;
 
+        internal Func<bool>? HasActiveDescendant { get; set; }
+
         internal string? GetActiveDescendantId()
         {
+            if (HasActiveDescendant != null && !HasActiveDescendant())
+            {
+                return null;
+            }
+
             return $"{GetId()}-active-item";
         }
 
diff --git a/Radzen.Blazor/RadzenDropDownDataGrid.razor.cs b/Radzen.Blazor/RadzenDropDownDataGrid.razor.cs
index a8d02fe81..c5fc6bdfd 100644
--- a/Radzen.Blazor/RadzenDropDownDataGrid.razor.cs
+++ b/Radzen.Blazor/RadzenDropDownDataGrid.razor.cs
@@ -561,6 +561,11 @@ namespace Radzen.Blazor
         {
             isFirstRender = firstRender;
 
+            if (grid != null)
+            {
+                grid.HasActiveDescendant ??= () => selectedIndex >= 0;
+            }
+
             if (firstRender)
             {
                 if(Visible && LoadData.HasDelegate && Data == null)